Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1548 | CA16085 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 117 |
| 2 | AZT+ DDC | 108 |
| 3 | DDI | 95 |
| 4 | D4T | 30 |
| 5 | 3TC+ AZT | 39 |
| 6 | 3TC+ AZT+ IDV | 21 |
| 7 | 3TC+ D4T+ IDV | 12 |
| 8 | 3TC+ D4T+ NFV+ NVP | 21 |
| 9 | 3TC+ D4T+ NFV+ SQV | 39 |
| 10 | D4T+DDI+NFV+SQV | 87 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, K43T, F53L | L10I, E35D, M36I, I62V, L63P, I64V, G73V, T74S |
| >CA16085| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEDINLPGRWTPKIIGGIGGLVKVRQYD QVPVEICGHKAIVSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215Y | K219E | K11KR, K20R, V60I, V118I, D123E, S162Y, I178M, V179I, T200A, E203D, D218E, L228H, Q242H, I293V, A304G |
| >CA15798| codons 1-304 PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRAKIDELRQHLLRWGFYTPEEKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELG |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |