Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6497 | CA16031 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 52 |
| 2 | 3TC+D4T+IDV | 182 |
| 3 | 3TC+D4T+NFV+NVP | 95 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | G190A | K101H | T39TA, I135T, I142V, S162C, S251SN, K277R, Q278H, D324DE, A360AT, K366KR, T369TA, A371AV, I375IV, A376AST, K390KR, A400T, E404ED, V417VI, T419TI, V435VA, K451KR, D460DN, R461RK, S468SP, T470TA, H483HY, L491LPS, S519SN, Q524QE, A554ST, I556IV, K558KR, V559VI | T286AG, A299AG |
| >CA16031| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDNWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGAKALTEVIPLTEEGE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLAEVVQKVTTESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFINIP PLVKLWYQLEKEPIAGAETFYVDGAANRETRLGKAGYVTNKGRQKVVPLADTTNQKTELQ AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKEKVYLAWVPAHK GIGGNEQVDKLVSTGVRRIL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F | I62V, L63P, A71V, I93L |
| >CA16294| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |