Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6462 | CA15979 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 104 |
| 2 | 3TC+AZT | 26 |
| 3 | 3TC+D4T | 197 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q, N348NI | K101R, K102Q, K122KE, D123DN, I135L, I142IT, K166R, Q207H, R211K, L228LH, A272P, K275R, Q278H, T286A, I293IL, E300EG, V317VA, Q334P, P345A, G359S, V365VI, K366R, A371V, A376V, A400T, T403S, L452LS, D460N, S468T, H483Y, L491S, K512R, S519N, V531I, K550R, A554T, K558R | D471DA |
| >CA15979| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRQKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSLNNETPGTRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRHHLLKWGFTTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCKLLRGAKALTEVLPLTEEAG LELAENREILKEPVHGAYYDPSKDLIAEIQKQGPGQWTYQIYQEAFKILKTGKYARMRSA HTNDIRQLTEVVQKIVTESIVIWGKTPKFKLPIQKETWETWWSEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKSGKAGYVTNRGRQKVVTLTATTNQKTELQ AIYLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEQLIKKEKIYLAWVPAHK GIGGNEQVDRLVSTGIRRVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L19I, I62V, L63P, V77I, I93L |
| >CA16241| codons 1-99 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |