<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
300071 CP076300071 Zambia 2008 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I13X, I15V, L19I, E35D, M36MI, N37S, R41H, I62IV, L63LHQ, H69K, A71T, I93L  
>CP076300071| codons 1-99
PQITLWQRPLVSXKVGGQIKEALLDTGADDTVLEDISLPGHWKPKMIGGIGGFIKVRQYD
QVQIEICGKKTIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36EA, T39E, S48T, T69TS, R83X, F87X, Q91X, H96X, L100X, K122E, D123G, K173A, Q174K, D177E, I178IM, T200A, Q207G, R211K, V245Q, E248ED, A272P, I274IV, K277KR, Q278N, E291ED, V292I, I293V, L325M  
>CP076300071| codons 1-331
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSSKWRKLVDFRELNKXTQDXWEVXLGIPXPAGXKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEMVI
YQYMDDLYVGSDLEIGQHRAKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGVKVRNLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDMIAEIQK

References
Author Title Citation
Hamers, RL HIV-1 drug resistance mutations are present in six percent of persons initiating antiretroviral therapy in Lusaka, Zambia. JAIDS, 2010
Hamers, RL HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: A multicentre observational study. Lancet, 2011