Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2083 | CA15935 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 104 |
| 2 | AZT+ 3TC+ SQV | 17 |
| 3 | AZT+ 3TC+ IDV | 24 |
| 4 | DDI+ D4T+ IDV | 35 |
| 5 | 3TC+ D4T+ NVP | 23 |
| 6 | DLV+ SQV+ NFV | 29 |
| 7 | DLV+ D4T+ IDV | 16 |
| 8 | DDI+ 3TC+ D4T | 11 |
| 9 | DDI+ 3TC+ D4T+ RTV+ SQV | 16 |
| 10 | DDI+ 3TC+ D4T+ APV+ SQV+ ADV | 46 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K103N, Y181C | K43N, E44D, S48E, V118I, K122P, K166R, D177E, G196E, R211K, D218E, V245E, A272P, K277R, L283LI, I293V, E297R, V317A, D324E, Q334L, G359S, T369V, A371V, I375V, A376S, T377M, K390R, S468P, H483Y |
| >CA15935| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKIEKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTREAE LELAENREILKEPVHGAYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLVEVVQKVSMESIVIWGKTPKFRLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73C | L10I, K20I, I54X, D60E, L63PQ, I64V, V77I, I85V, I93IL |
| >CA16204| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFXKVRQYE QIPVEICGHKAICTVLIGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |