Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6392 | CA15887 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 12 |
| 2 | AZT+DDI | 65 |
| 3 | AZT | 34 |
| 4 | 3TC+AZT | 13 |
| 5 | D4T+DDC+IDV | 17 |
| 6 | 3TC+AZT+IDV | 13 |
| 7 | RTV+SQV | 17 |
| 8 | 3TC+AZT+DDC+NFV | 39 |
| 9 | D4T+DDI+NVP | 47 |
| 10 | ABC+D4T+EFV | 63 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184MI, L210W, T215Y | K219R | K103N, V106A | F227L | M16V, K20R, T39A, E44D, R83K, V118I, K122P, S162C, I178L, G196E, E203K, H208Y, R211D, K223E, E224D, A272P, K277R, T286A, E297KR, A304G |
| >CA15887| codons 1-304 PISPIETVPVKLKPGVDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSATVLDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYIDDLYVGSDLEIEQHRTKIKELRQYLWDWGFYTPDRKHQEDPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82VA | L10LI, M36I, I62V, L63P, A71V, V75VI |
| >CA16151| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVIGTILVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |