Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6373 | CA15866 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 157 |
| 2 | DDI | 48 |
| 3 | AZT+DDI+NVP | 122 |
| 4 | AZT+DDI+EFV | 41 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215Y | K219Q | K103N, G190A | I135T, T200A, Q207E, V245E, A272P | K259KT, N265NS |
| >CA15866| codons 1-280 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRAKIEELREHLLRWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQTLVGKLSWASQIYPGIKVKQLC |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T74TP | T12A, Q18QE, L19I, M36I, N37S, L63P |
| >CA16129| codons 10-99 LVAIKIGGEIKEALLDTGADDTVLEEISLPGRWKPKMIGGIGGFIKVRQYDQIPIEICGH KAIGPVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |