Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6359 | CA15845 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 31 |
| 2 | 3TC+D4T+NVP | 96 |
| 3 | 3TC+ABC+NVP | 37 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | K219Q | G190A | K238T | K20R, K32T, T39A, V60I, D67X, T69N, V118VI, K173R, Q174K, N175Y, G196E, R211S, F214L, D218E, T286A, V292I, I293V, E297K | R72RG |
| >CA15845| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKITALVEICAEMEKEGKISKIGPENPYNTPI FAIKKKXSNRWGKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKYPDIVI YQYVDDLYVASDLEIEQHRTKIEELRQHLLSWGLTTPEQKHQKEPPFLWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIVPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M36I, R41K, I62V, L63P, A71V, V77I, I93L |
| >CA16106| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKVIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |