Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4816 | CA15813 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 24 |
| 2 | 3TC+D4T+NFV | 21 |
| 3 | 3TC+DDI+NVP | 17 |
| 4 | DDI+NVP+RTV+SQV | 17 |
| 5 | ABC+EFV+NFV | 27 |
| 6 | 3TC+ABC+AZT+IDV+RTV | 34 |
| 7 | 3TC+ABC+APV+AZT+EFV+RTV | 23 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74LV | Y181C, G190GS | V35L, V106I, K122E, K173T, Q174R, T200TA, Q207E, R211K, F214L, H221Y, D237DE, A272P, K277R, I293V, P294A |
| >CA15813| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTRNPDIVI CQYMDDLYVSSDLEIGQHRAKIEELREHLLKWGLTTPDKKYQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVALTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN | N88ND | I3IF, L10I, I13IV, K14R, I15V, N37D, K45KR, R57RK, I62V, L63PS, H69HY, I72IT, V77I, I93L |
| >CA16050| codons 1-99 PQFTLWQRPIVTVRVGGQLKEALLDTGADNTVLEEMDLPGRWKPRMIGGIGGFIKVKQYD QVPIEICGYKATGTVLIGPTPVNIIGRDLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |