Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Y0506 | Y0506 | U.S. | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, H69K, L89M |
| >Y0506| codons 1-99 PQITLWQRPLVTVKVGGQLREALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K11T, V35T, S48T, V60I, D121H, K122E, D123S, I142V, K173S, Q174E, D177E, T200A, Q207A, R211N, V245E, D250E, A272P, T286A, E291D, V292I, P294T, E312D, G335D, M357T, G359S, T369S, A371V, I375V, A376T, T377R, A400T, E404D, E432D, S468P, Q480H, L491S, K512R, E514D, L517I, S519N, Q524E, K527R, E529D, A534S, A554S | G462GR |
| >Y0506| codons 1-560 PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSENPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLNWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIITLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLSEVVQKVTRESIVIWGKTPKFKLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTDRRRQKVVPLTDTTNQKTELH AIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSDSEIVNQIIEELIRKDKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, R20K, V31I, M50R, I72V, L101I, T112V, I113V, T124A, T125A, K136Q, D167E, G193E, V201I, T218I, L234I | S283G |
| >Y0506| codons 1-288 FLDGIDKAQEEHERYHSNWKAMASDFNLPPIVAKEIVASCDKCQLKGEARHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVVHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGEYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. | PLoS Med, 2009 |