<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
V2537 V2537 U.S. 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, G17D, L19I, M36I, N37K, R41K, Q61D, L63S, H69K, I93L  
>V2537| codons 1-99
PQITLWQRPLVSIKVGDQIKEALLDTGADDTVLEEIKLPGKWKPKMIGGIGGFIKVRQYD
DISIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36AV, T39E, S48T, K122E, D123G, S162C, E169A, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K281R, T286A, E291D, V292I, S322T, D324E, Q334H, G335D, R356K, G359T, A376T, T377M, K390R, A400T, E404D, V435G, A437V, L452I, V466I, D471E, H483Q, L484LI, L491P, S519N, K527N, K530R, A554S  
>V2537| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTVICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILAPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTDIIPLTEEAE
LELAENREILKEPVHGVYYDPTKELIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKITMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIGGVETFYVDGAANRETKIGKAGYVTDRGRQKIVSLTETTNQKTELQ
AIQIALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERVYLAWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009