<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
V2503 V2503 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, R20K, K34R, L101I, S119R, S123C, G193E, T206S, I208IM, D256E D286N
>V2503| codons 1-288
FLDGIDKAQEEHERYHSNWKAMASDFNLPPVVAREIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGRN
FTCTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGEYSAGERIVDIIASDMQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQNED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    K20R, E35D, N37S, R41K, I62IV, L63P, I93L  
>V2503| codons 1-99
PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEDMSLPGKWKPKMIGGIGGFIKVRQYD
QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        D17DE, V35VL, S68G, T69TI, D123E, S162C, P170PS, T200A, Q207K, R211K, L228H, K277R, T286A, A288S, I293V, E297K, I309V, G333E, T338S, K390R, A400T, V435L, D460N, Q480H, H483Q, S519T, L533M, A554NT H96HL, P97PR, K350K*
>V2503| codons 1-560
PISPIETVPVKLKPGMEGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDGIKWRKLVDFRELNKRTQDFWEVQLGIPLRAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILESFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELRKHLLKWGFTTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKSLTEVVPLTKEAE
LELAENREVLKEPVHGVYYDPSKDLIAEIQKQEQGQWSYQIYQEPFKNL*TGKYARMRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPILGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLTDTTNQKTELH
AIQLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVTQIIEQLIKKEKVYMAWVPAHK
GIGGNEQVDKLVSTGIRKVL

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009