Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| S0531 | S0531 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| A128AT | I72V, L74I, T122I, T124A, I208L |
| >S0531| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN FISATVKTACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDLQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L63P, I93L |
| >S0531| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K122E, I135T, I142T, G196E, F214L, V245E, V292I, I293V, M357T, V365I, K390R, A400S, D460N, R461K, L491A, E516D, Q524E |
| >S0531| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWESWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVSLTDTTNQKTELQ AIHLALQDSGAEVNIVTDSQYALGIIQAQPDKSESDLVSQIIEELIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. | PLoS Med, 2009 |