Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| R4543 | R4543 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35I, T39S, R83K, V118I, D121H, K122E, K173E, D177E, I178L, R211K, F214L, A272P, K277R, I293V, I329V, G333D, Q334H, M357S, T369A, K390R, A400T, V435I, H483HY, L491LS, A502S, S519N, Q520QK, K527N, A554T |
| >R4543| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICSEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPELVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQDHGQWTYQIYQEPFKNLKTGKYARSRGA HTNDVKQLAEAVQKIATESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ AIYLALQDSGSEVNIVTDSQYSLGIIQAQPDKSESELVNKIIEQLINKEKVYLAWVPAHK GIGGNEQVDKLVSTGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M36I, Q61D, L63S, I64L | R41*K |
| >R4543| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD DISLEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, M50MI, I72V, L101I, T124A, A205S, I208L, E212EA, I220L, Y227F, A265V |
| >R4543| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGSN FTSATVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIISTDLQTKALQKQITKLQNFRVYFRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. | PLoS Med, 2009 |