Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| R0500 | R0500 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K64R, K104R, K122E, D123E, I135V, T139A, K173E, T200A, I202V, E248D, D250N, A272P, I293V, G333D, Q334H, M357T, A376S, T377L, K390R, A400I, V435I, A446S, D460N, R461K, S468T, L491S, I506L, S519N, A534S | P1PS, E302EG |
| >R0500| codons 1-560 SISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIRKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDIVI YQYMDDLYVGSDLEIGQHRAKVEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDKNSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LGLAENREILKEPVHGVYYDPSKDLIAEIQKQDHGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKISLESIVIWGKTPKFRLPIQKETWEIWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGASNRETKLGKAGYVTNKGRQKVVTLTDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGILQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSAGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12I, I62V, L63P, V77I |
| >R0500| codons 1-99 PQITLWQRPLVIIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, V31I, M50I, T124A, V201I, T218S, K219N, I220L, N222K, D256E, R269K |
| >R0500| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN FTSATVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQISNLQKFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKAKIIKDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. | PLoS Med, 2009 |