<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    M50I, S57N, I72V, L101I, T112A, T125A, I135V, Y194C, V201I, T206S, I220L, Y227F, N254K, A265V  
>Q3531| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAIHGQVDCNPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKAIHTDNGSN
FTSTAVKAACWWAGVKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGCSAGERIIDIIASDIQTKELQKQITKLQNFRVYFRDSRDPLWKGPAK
LLWKGEGAVVIQDKSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, R41K, L63P, L89M K20K*
>Q3531| codons 1-99
PQITLWQRPLVTVKIGGQL*EALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  T215C K103N   K11R, K122E, D123N, I135T, I142V, A158S, S162C, E169D, G196E, I202V, L210M, F214L, A272P, E297R, V317A, D324E, G333E, Q334H, T338S, T377L, K390R, V435I, D460N, V467I, G490D, L491S, S519N, Q520L, A554S K20KT
>Q3531| codons 1-560
PISPIETVPVRLKPGMDGPTVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPSIFQCSMTKILDPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRTKVEELRQHLMRWGLCTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTREAE
LELAENREILKEPVHGAYYDPSKELIAEIQKQEHGQWSYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWEAWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTNRGRQKVISLTDTTNQKTELQ
AIHLALQDSDSEVNIVTDSQYALGIIQAQPDKSESELVNLIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009