<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, L28I, S39C, I84M, L101I, T124A, M154L, V201I, K240R  
>P4505| codons 1-287
FLDGIDKAQEEHERYHSNWRAMASDFNIPPVVAKEIVACCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYMEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGSN
FTSATVKAACWWAGIKQEFGIPYNPQSQGVVESLNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAR
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12E, I15V, L19I, M36I, R57K, I62V, L63T, A71V, I93L  
>P4505| codons 1-99
PQITLWQRPLVEIKVGGQIKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVKQYD
QVTIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L T215S     V35T, I50V, V60I, K122P, D123E, I135T, I142V, K166R, D177E, T200A, R211D, A272P, K277R, I293V, E297R, L301I, A304E, K311R, V317A, I329V, Q334N, G335D, G359S, A376T, S379C, K390R, E399D, A400T, E404D, V435I, K454R, R463K, L491S, V531I  
>P4505| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKVGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DPEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRQHLLDWGFSTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE
IELEENREILREPVHGAYYDPSKDLIAEVQKQGNDQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKITTECIVIWGKTPKFRLPIQKETWDTWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGRAGYVTDRGKQKVVSLTDTTNQKTELQ
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKIYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009