<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D6E, E10D, E11D, S17N, D25E, V31I, M50T, I72V, L101I, S119P, T122I, T124A, T125A, K160T, I161IL, T206S  
>O1570| codons 1-288
FLDGIEKAQDDHEKYHNNWRAMASEFNLPPIVAKEIVASCDKCQLKGEATHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGPN
FISAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKTLIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIASDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  V82VD E35D, N37D, L63P, C67S, A71T  
>O1570| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD
QIPIEISGHKTIGTVLVGPTPDNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        P14X, K122E, D123G, D177E, V189I, R211K, I293V, P294Q, S322T, D324E, Q334E, A360T, K366R, A376T, A400S, E404D, R448RK, E449ED, L452LS, D460N, T470N, H483L, L517V, Q524E  
>O1570| codons 1-560
PISPIETVPVKLKRGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYIGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVQLTEEAE
LELAENREILKEPVHGVYYDPTKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVRQLTEAVQKITTESIVIWGKTPKFKLPIQKETWESWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANKDTKSGKAGYVTNRGRQKVVSLNDTTNQKTELQ
AILLALQDSGLEVNIVTDSQYALGIIQAQPDKSESEVVSQIIEELIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009