Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| N4510 | N4510 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K7KR, S17N, V31I, L63I, I72V, L74I, L101I, K111T, S119T, T124A, I135V, K173R, V176L, T206S, D207E, D256E |
| >N4510| codons 1-288 FLDGIDRAQEEHEKYHNNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQIDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVTTIHTDNGTN FTSATVKAACWWAGVKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLRTALQMAV FIHNFKRKGGIGGYSAGERIVDIIASEIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L63P, K70T, N98NK |
| >N4510| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHTAIGTVLVGPTPVNIIGRNLLTQIGCTLKF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| I2IL, V35M, R83K, K122E, T200E, R211RK, V245E, E248D, S322SL, G359S, A360AS, A371V, A376T, V381VI, K390R, A400T, E404ED, L469F, G490X, L491X, T497S, L503I, L517I, A534S | S3SN, G335GRS, Q340Q* |
| >N4510| codons 1-560 PLNPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHREKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPLKDLIAEIQKQGQSQWTY*IYQEPFKNLKTGKYARMRSS HTNDVKQLTEVVQKITTESIIIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSFTDTTNQKTELQ AIHLALQDSXXEVNIVSDSQYAIGIIQAQPDKSESEIVSQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. | PLoS Med, 2009 |