<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
N4510 N4510 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K7KR, S17N, V31I, L63I, I72V, L74I, L101I, K111T, S119T, T124A, I135V, K173R, V176L, T206S, D207E, D256E  
>N4510| codons 1-288
FLDGIDRAQEEHEKYHNNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQIDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVTTIHTDNGTN
FTSATVKAACWWAGVKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLRTALQMAV
FIHNFKRKGGIGGYSAGERIVDIIASEIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, L63P, K70T, N98NK  
>N4510| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHTAIGTVLVGPTPVNIIGRNLLTQIGCTLKF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        I2IL, V35M, R83K, K122E, T200E, R211RK, V245E, E248D, S322SL, G359S, A360AS, A371V, A376T, V381VI, K390R, A400T, E404ED, L469F, G490X, L491X, T497S, L503I, L517I, A534S S3SN, G335GRS, Q340Q*
>N4510| codons 1-560
PLNPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHREKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPLKDLIAEIQKQGQSQWTY*IYQEPFKNLKTGKYARMRSS
HTNDVKQLTEVVQKITTESIIIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSFTDTTNQKTELQ
AIHLALQDSXXEVNIVSDSQYAIGIIQAQPDKSESEIVSQIIEQLIKKEKVYLSWVPAHK
GIGGNEQVDKLVSAGIRKVL

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009