<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
N1505 N1505 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S17N, V32I, I72V, L101I, I135IV, G193E, T206S, R262RK, A265AV, D278DN D6EK, D286N
>N1505| codons 1-288
FLDGIKKAQEEHEKYHNNWRAMASDFNLPPVIAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGVKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGEYSAGERIVDIIASDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPKRKVKIIRDYGKQMAGNDCVASRQNED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, T12TK, E35D, N37D, R41K, I62V, L63H, A71T, I72V, P79S  
>N1505| codons 1-99
PQITLWQRPIVKIKIGGQLKEALLDTGADDTVLEDMDLPGKWKPKMIGGIGGFIKVRQYD
QVHIEICGHKTVGTVLVGSTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        I135M, S162SN, T165TA, T200A, K201R, Q207QL, H208HL, A272P, K277R, T286A, P294S, I329L, G333E, T369A, K374R, I375V, A376T, T386I, K390R, A400T, L452S, I482V, L491V, A502V, E516ED, S519N, K530R, A554T K126KE, E233Y, L234F, H235I
>N1505| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFREYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQNSMAKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRARIEELRLLLLRWGFTTPDKKHQKEPPFLWMGYYFIPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVISLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLAEAVQRVTTESIVIWGKIPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKSGKAGYVTDRGRQKVVSLTDTTNQKTELQ
AVHLALQDSGVEVNIVTDSQYVLGIIQAQPDKSESDLVNQIIEQLIKKERVYLAWVPAHK
GIGGNEQVDKLVSTGIRKVL

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009