Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| M8528 | M8528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10I, I15V, L19I, M36I, N37E, R57K, D60E, L63P, H69K, I85V |
| >M8528| codons 1-99 PQITLWQRPIVTIKVGGQIKEALLDTGADDTVLEEIELPGRWKPKMIGGIGGFIKVKQYE QIPIEICGKKAIGTVLVGPTPVNIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V10I, T27S, A98S, D121Y, K122E, F171Y, D177G, V179I, T200A, R211K, V245E, E248D, A272P, K277R, L283I, V292I, E297K, Q334H, K366R, K390R, A400S, E404D, V435A, G436E, D460S, Q480K, H483Y |
| >M8528| codons 1-494 PISPIETVPIKLKPGMDGPKVKQWPLSEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPGIII YQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQKETWESWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAEAETFYVDGAANRETKLGKAGYVTSRGRQKVVSLTDTTNQKTELK AIYLALQDSGLEVN |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. | PLoS Med, 2009 |