<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
M6571 M6571 U.S. 2003 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    E35D, M36I, R41K, R57RK, L63P, H69K, L89M, I93L  
>M6571| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, E28EK, V35T, T39E, S68G, V106I, K122E, D123S, K173R, Q174K, D177E, I178M, E203D, Q207A, R211S, V245Q, E248D, D250E, T286A, E291D, V292I, I293V, E298EG, K311Q, E312T, I326V, A327AT, I329V, Q334QE, G335GD, M357N, G359S, K366R, A371V, I375IV, K390R, K395R, A400T, T403M, E432D, N447S, R463RK, D471E, Q480H, H483Q, L491S, K512R, E516EV, L517IV, S519N, A534S, A554AS, K558R G333GW, L486L*, D498DV, Q524EV
>M6571| codons 1-560
PISPIDTVPVKLKPGMDGPKVKQWPLTKEKIKALTEICEEMEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPEMVI
YQYMDDLYVGSDLEIGQHRTKIDELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTEGAE
LELAENREILQTPVHGVYYDPSKDLVTEVQKQWEDQWTYQIYQEPFKNLKTGKYARNRSA
HTNDVRQLTEVVQKVATESIVIWGKTPKFRLPIQRETWETWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAASRETKLGKAGYVTDRGKQKVVSLTETTNQKTELH
AIQLA*QDSGSEVNIVTVSQYALGIIQAQPDRSESVVVNQIIEVLIKKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRRVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, V31I, I72V, G106GA, T112V, S119P, T125A, G134N, I135V, K136R, D167E, G193E, V201I, L234I S283G, R284G, D286DN, D288N
>M6571| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAARWPVKVIHTDNGPN
FTSTAVKAACWWANVRQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGEYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGGQNEN

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009