Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E11D, S24N, D25E, S57N, Q95P, L101I, S119P, K136N, K156N, Q177L, V201I, I203M, I208L, T218S |
| >K7576| codons 1-288 FLDGIDKAQEDHEKYHSNWRAMANEFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCNPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGPETAYFILKLAGRWPVKTIHTDNGPN FTSTTVKAACWWAGINQEFGIPYNPQSQGVVESMNNELKKIIGQVRDQAEHLKTAVLMAV FIHNFKRKGGIGGYSAGERIIDMIATDLQTKELQKQISKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37T, R57K, D60E, Q61D, I62V, L63S, I72V, V77I, I93L |
| >K7576| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMTLPGRWKPKMIGGIGGFIKVKQYE DVSIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35X, K122E, I178M, T200A, Q207E, V245M, E248N, D250A, A272P, K277R, T286A, Q334H, A376T, S379C, A400S, S468P, L469I, K512T, S519N, Q524E, V531I, Q547K |
| >K7576| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALXEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPNKASWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTECIVIWGKTPKFKLPIQKETWESWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPITDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDTSESELVNQIIEELIKKEKIYLAWVPAHK GIGGNEKVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. | PLoS Med, 2009 |