<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, S24N, D25E, S57N, Q95P, L101I, S119P, K136N, K156N, Q177L, V201I, I203M, I208L, T218S  
>K7576| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMANEFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCNPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGPETAYFILKLAGRWPVKTIHTDNGPN
FTSTTVKAACWWAGINQEFGIPYNPQSQGVVESMNNELKKIIGQVRDQAEHLKTAVLMAV
FIHNFKRKGGIGGYSAGERIIDMIATDLQTKELQKQISKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    N37T, R57K, D60E, Q61D, I62V, L63S, I72V, V77I, I93L  
>K7576| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMTLPGRWKPKMIGGIGGFIKVKQYE
DVSIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35X, K122E, I178M, T200A, Q207E, V245M, E248N, D250A, A272P, K277R, T286A, Q334H, A376T, S379C, A400S, S468P, L469I, K512T, S519N, Q524E, V531I, Q547K  
>K7576| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALXEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIMLPNKASWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTECIVIWGKTPKFKLPIQKETWESWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPITDTTNQKTELQ
AIHLALQDSGLEVNIVTDSQYALGIIQAQPDTSESELVNQIIEELIKKEKIYLAWVPAHK
GIGGNEKVDKLVSAGIRKVL

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009