Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| K1573 | K1573 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33I | N37T, I62V, L63P, I64V, V77I, I93L |
| >K1573| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMTLPGRWKPKMIGGIGGFIKVRQYD QVPVEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6D, V35T, E36D, K122E, K173E, I178M, Q207K, R211K, A272P, K277R, V292I, I326V, Q334Y, M357V, T369A, K390R, A400L, R461K, R463K, H483Y, A508S, S519N, Q524E, A534T, Q547K, A554N, K558R |
| >K1573| codons 1-560 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTDICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRKHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIIPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGYGQWTYQIYQEPFKNLKTGKYARVRGA HTNDVKQLAEAVQKIATESIVIWGKTPKFRLPIQKETWELWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDKGKQKVVSLTDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQSQPDKSESELVNQIIEELIKKEKVYLTWVPAHK GIGGNEKVDKLVSNGIRRVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E11D, S24N, L101I, T112V, S119P, K136N, V201I, T218I, N254Q, S255G |
| >K1573| codons 1-288 FLDGIDKAQEDHEKYHSNWRAMANDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGPN FTSTTVKAACWWAGINQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDQGDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. | PLoS Med, 2009 |