<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
K1573 K1573 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L33I N37T, I62V, L63P, I64V, V77I, I93L  
>K1573| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMTLPGRWKPKMIGGIGGFIKVRQYD
QVPVEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, V35T, E36D, K122E, K173E, I178M, Q207K, R211K, A272P, K277R, V292I, I326V, Q334Y, M357V, T369A, K390R, A400L, R461K, R463K, H483Y, A508S, S519N, Q524E, A534T, Q547K, A554N, K558R  
>K1573| codons 1-560
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTDICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDMVI
YQYMDDLYVGSDLEIGQHRTKIEELRKHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGYGQWTYQIYQEPFKNLKTGKYARVRGA
HTNDVKQLAEAVQKIATESIVIWGKTPKFRLPIQKETWELWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDKGKQKVVSLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQSQPDKSESELVNQIIEELIKKEKVYLTWVPAHK
GIGGNEKVDKLVSNGIRRVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, S24N, L101I, T112V, S119P, K136N, V201I, T218I, N254Q, S255G  
>K1573| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMANDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGPN
FTSTTVKAACWWAGINQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDQGDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

References
Author Title Citation
Brumme, ZL HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. PLoS Med, 2009