Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| G8500 | G8500 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | E35G, M36I, I62V, L63P |
| >G8500| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEGINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215S | Y181C | V179D, Y318F | S68G, K103R, K122E, D123S, I135V, S162C, R211K, H221Y, V245E, E248EK, A272S, I293V, H315Y, M357V, T377TI, T386I, E399D, A400T, V435A, E449G, K454R, T470P, K512Q, S519N, K527N |
| >G8500| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIDI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFSTPDKKYQKEPPFLWMGYELHPDKWT VQPIELPKKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVYGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA HTNDVKQLTEAVQKIAIESIVIWGKIPKFKLPIQKETWDTWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRGTKLGRAGYVTDRGRQKVVSLPDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLINKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. | PLoS Med, 2009 |