Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| G3542 | G3542 | U.S. | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12IKM, G16GE, E35D, M36L, N37E, R41K, R57K, I62V, L63T, I64V, H69Y |
| >G3542| codons 1-99 PQITLWQRPLVMIKIEGQLKEALLDTGADDTVLEDLELPGKWKPKMIGGIGGFIKVKQYD QVTVEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y188YC | K20R, V35IT, T39TA, S68SG, T69TN, K122E, I135V, I142L, Y144YF, K166R, I202V, R211K, F214L, V245M, K277R, T286A, I293V, E297K, A304E, E312N, I329V, Q334QH, G335GD, R356K, M357A, G359S, T362TN, T369S, T377L, A400T, V435A, A437V, H483Y, Q507H, A554T | V111VG, G333AE |
| >G3542| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPV FAIKKKDGNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDGGDAYFSVPL DEDFRKYTAFTIPSVNNETPGLRFQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLCVGSDLEIGQHRTKVEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE LELEENREILKNPVHGVYYDPSKDLIAEVQKQEHDQWTYQIYQEPFKNLKTGKYAKARSA HNNDVKQLSEAVQKIALESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGVETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIHAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSTGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E11D, E13D, L101I, I113V, T124A, I220L | K186K* |
| >G3542| codons 1-288 FLDGIDKAQEDHDKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTVHTDNGSN FTSATVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNF*RKGGIGGYSAGERIVDIIATDIQTKELQKQITKLQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. | PLoS Med, 2009 |