Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JF10 | JF10-12w | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV | 48 |
| 2 | SQV | 20 |
| 3 | AZT | 96 |
| 4 | DDI | 116 |
| 5 | DDC | 56 |
| 6 | D4T | 52 |
| 7 | 3TC | 52 |
| 8 | PFA | 36 |
| 9 | ABC+APV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T, L90M | G73S | L10R, N37D, I62V, L63P, A71V, V77I, I93L |
| >JF10-12w| codons 1-99 PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPTNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LI, V75T, M184I, L210W | T215C, K219R | V108I | V118I, K122E, I178M, G196E, E203K, R211E |
| >JF10-12w| codons 24-260 WPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKNSDKWRKITDFRELNKR TQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIR YQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIYQYIDDLYVGSDLEIEQHRTKIK ELRQHLWEWGFCTPDRKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Falloon, J | Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity. | Clin Infect Dis, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |