Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JF09 | JF09-0w | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV | 104 |
| 2 | SQV | 12 |
| 3 | AZT | 255 |
| 4 | DDI | 48 |
| 5 | DDC | 92 |
| 6 | D4T | 48 |
| 7 | 3TC | 44 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, L90M | V11VI | L10I, T12E, I15V, L19I, R41K, L63P, A71T |
| >JF09-0w| codons 1-99 PQITLWQRPIIEIKVGGQIKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPIEICGHKTIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, M184V, T215F | D67G, K219Q | S68G, V118I, I135T, Q197QK, F214L, D218DE |
| >JF09-0w| codons 25-258 PLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKGGDRWRKLVDFRELNKRT QDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRY QYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGKHRTKIEE LRQHLLRWGLFTPEQKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQ |
References
| Author | Title | Citation |
| Falloon, J | Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity. | Clin Infect Dis, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |