Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JF08 | JF08-12w | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV | 72 |
| 2 | SQV | 24 |
| 3 | AZT | 104 |
| 4 | DDI | 32 |
| 5 | DDC | 8 |
| 6 | D4T | 16 |
| 7 | 3TC | 44 |
| 8 | ABC+APV | 6 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, L90M | L10I, I15V, E35D, N37E, K45R, L63P, A71V, I93L, C95F |
| >JF08-12w| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMELPGRWKPRMIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPTNIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215F | D67G, K219Q | K43Q, K64R, T69N, V118I, F171Y, G196N, T200I, I202V, E204Q, Q207E, R211K, F214L, L228LH, V245T |
| >JF08-12w| codons 24-260 WPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPVFAIRKKGSNRWRKIVDFRELNKR TQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIR YQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPDIVIYQYVDDLYVGSDLEINQHRIKVE QLREHLLKWGLFTPDQKHQKEPPFHWMGYELHPDKWTVQPITLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Falloon, J | Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity. | Clin Infect Dis, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |