Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JF02 | JF02-0w | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV | 72 |
| 2 | RTV | 28 |
| 3 | SQV | 24 |
| 4 | AZT | 228 |
| 5 | DDI | 160 |
| 6 | DDC | 12 |
| 7 | D4T | 36 |
| 8 | 3TC | 56 |
| 9 | NVP | 24 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33I, G73S | L10I, K14R, E35D, M36I, I62V, L63P, A71V, I93L |
| >JF02-0w| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVIEDINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74I, M184V, T215F | T69G, K219Q | K103N | A98AG | V35I, K43E, S48T, K66X, D67X, K122E, I135M, V179I, G196E, L228H |
| >JF02-0w| codons 35-258 IEICTEMEEEGKITKIGPENPYNTPVFAIKKXXSGRWRKIVDFRELNKRTQDFWEVQLGI PHPGGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWK GSPAIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGF FTPDQKHQKEPPFHWMGYELHPDKWTVQPIVLPEKDSWTVNDIQ |
References
| Author | Title | Citation |
| Falloon, J | Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity. | Clin Infect Dis, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |