Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6800 | CA14925 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 170 |
| 2 | AZT+DDI | 56 |
| 3 | 3TC+AZT | 22 |
| 4 | 3TC+AZT+SQV | 4 |
| 5 | 3TC+AZT+RTV | 65 |
| 6 | D4T+DDI+NVP | 39 |
| 7 | DDC+RTV+SQV | 39 |
| 8 | 3TC+ABC+EFV+RTV+SQV | 17 |
| 9 | APV+D4T+DDI | 41 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V | L33LF | K20R, E35D, M36IL, N37T, F53I, R57K, I62V, L63P, V77I, I85V |
| >CA14925| codons 12-99 TIKIGGQLREALLDTGADDTVFEDITLPGRWKPKMIGGIGGIIKVKQYDQVPIEICGHKA IGTVLIGPTPVNVVGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75T, Q151M, T215F | A62V, K219Q | K103N, Y188L | K20R, I31R, T39A, A98S, V118I, K122KE, R172K, V179I, I202V, F214L, L228H, T286A, V292I |
| >CA14775| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKRKALVEICAELEKEGKISKIGPENPYNTPV FVIKKKNSDKWRKLTDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIII YQYMDDLLVGSDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIIPLTEEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |