Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1828 | CA14918 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 59 |
| 2 | 3TC+AZT+SQV | 5 |
| 3 | 3TC+AZT+NFV | 32 |
| 4 | AZT+NFV | 5 |
| 5 | 3TC+AZT+NFV | 61 |
| 6 | None | 18 |
| 7 | EFV+D4T+APV+RTV | 4 |
| 8 | NVP+D4T+APV | 26 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T | L24I | L10I, Q18E, N37D, L63P, I64V, T74S, V77I, I93L | P9PS |
| >CA14918| codons 1-99 PQITLWQRSIVTIKIGGELKEALIDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAIGSVLIGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | K103N, Y181YC | K20R, D121Y, K122E, I135T, Q197K, Q207E, R211K, I293V, E297K | T253TS, N265NY, Q269QH, K281KE |
| >CA14769| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGKHRTKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWSVNDIQKLVGKLYWASHIYAGIKVKQLCELLRGTKALTEVVPLTKEAE LEL |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |