Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5990 | CA14913 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT+SQV | 126 |
| 3 | 3TC+D4T+NFV | 90 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | K20V, E35D, M36I, I62V, L63P, I64V, T74S |
| >CA14913| codons 1-99 PQITLWQRPLVTIKIGGQLVEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPVEICGHKAIGSVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210W, T215Y | K219E | K20R, V35K, T39A, T69TN, W88C, A98AS, K122E, D123E, K154KE, S163SR, G196E, T200A, E203K, F214L | N136NS, R211*K |
| >CA14766| codons 1-219 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALKEICAELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFCEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSISNETPGIRYQYNVLPQGWEGSPAIFQSRMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKIKELRQHLWKWGLYTPDE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |