Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3977 | CA14912 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 43 |
| 2 | AZT+ 3TC | 39 |
| 3 | AZT+ 3TC+ IDV | 22 |
| 4 | D4T+ 3TC+ SQV | 23 |
| 5 | DDI+ 3TC+ RTV | 25 |
| 6 | None | 20 |
| 7 | D4T+ NVP+ NFV | 32 |
| 8 | DDI+ 3TC+ ABC+ RTV+ SQV | 2 |
| 9 | None | 51 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, G16E, E35D, N37S, R41K, L63T, I72V, V77I | R8RG |
| >CA14912| codons 1-99 PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEDMSLPGKWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L | A98AG | K20R, V35I, E44ED, V60VI, R83RK, K103KR, D123E, T165TI, H208HY, L210LV, R211K, T215X, A272P, K277R, I293V, E297K |
| >CA14765| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLKKRKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLVKWGFXTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |