Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5979 | CA14901 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | NA |
| 2 | 3TC+AZT+D4T+DDC+DDI+NVP+NFV+RTV | NA |
| 3 | NFV+RTV | 39 |
| 4 | DDI+NFV+RTV | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84IV, L90M | F53FL, G73C | L10I, K20R, E35D, M36I, N37D, I62V, L63A, I64V, T74S, V77VI |
| >CA14901| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKIIGGIGGLIKVRQYD QVAVEICGHKAICSVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, M184MV, L210W, T215F | K219Q | K103N, Y181C | K238T | P9T, K20R, V35VI, K43Q, A98S, V118I, K122E, I135V, S162Y, H208Y, R211K, D218E, L228H |
| >CA14751| codons 1-258 PISPIETVTVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFFTPEQKHQKEPPFHWMGYELHPDTWT VQPIVLPEKDSWTVNDIQ |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |