Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5954 | CA14899 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 74 |
| 2 | D4T+DDI+NFV | 127 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | L10LI, I13V, N37A, I62V, L63P, A71T, V77I |
| >CA14899| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADNTVLEEMALPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L210W, T215Y | V35M, T39A, K43Q, S68SG, V106I, V118I, K122E, D123E, I135IT, I142V, D177E, I178M, G196GE, R211K, V245VIM, A272P, T290TA, I293V |
| >CA14718| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEQEGKISKIGPENPYNTPV FAIKKKNGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALAEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive value of HIV-1 genotypic resistance test interpretation algorithms. | J Infect Dis, 2009 |