Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5975 | CA14891 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ NFV | 30 |
| 2 | IDV+ AZT+ 3TC | 21 |
| 3 | DLV+ NFV+ D4T | 48 |
| 4 | ABC+ AZT+ 3TC+ APV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F | L10I, N37T, R41K, D60E, I62V, L63P, I64V, I93L |
| >CA14891| codons 10-99 IVTIKIGGQLKEALLDTGADDTVLEEMTLPGKWKPKMIGGIGGFVKVRQYEQVPVEICGH KAIGTVLVGPTPFNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, L210LW, T215Y | K103N | M41X, R83K, Q207H, R211K, A272P |
| >CA14744| codons 1-279 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEXEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRHHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |