Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5964 | CA14877 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 21 |
| 2 | D4T | 47 |
| 3 | 3TC | 8 |
| 4 | 3TC+SQV | 8 |
| 5 | 3TC+RTV+SQV | 4 |
| 6 | 3TC+IDV | 43 |
| 7 | 3TC+DDI | 8 |
| 8 | 3TC+DDC+DDI+NFV | 4 |
| 9 | 3TC+DDI+NFV+NVP | 26 |
| 10 | D4T+ 3TC+NFV+NVP | 61 |
| 11 | ABC+ APV+ EFV | 39 |
| 12 | ABC+ APV+ D4T+ EFV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | K43T, G73A | L10I, Q18QH, K20I, L63P, A71T |
| >CA14877| codons 1-99 PQITLWQRPIVTIKIGGHLIEALLDTGADDTVLEEMNLPGRWTPKIIGGIGGFIKVRQYD QIPIEICGHKTIATVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, V75T, Y115F, Q151M | Y181C, G190A | V108I, F227L | K20R, S68G, V111I, I135L, S162SN, I178L, F214L, H221Y, V245E, A272P, K277R, E297A |
| >CA14729| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKVTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDIGDAFFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPMGWKGSPAIFQNSMTKILEPFRKQNPDLVI CQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTPDKKYQKEPPLLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTAEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |