Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5998 | CA14776 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 157 |
| 2 | 3TC+D4T+IDV | 180 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215Y | K219Q | K101Q, K122E, T131TP, E169D, D177E, V179VI, G196E, T200A, E203ED, Q207E, H208HY, F214L, V245T, E248V, A272P, R284K, I293V | K281KE |
| >CA14776| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFPIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIII YQYVDDLYVGSDLEIEQHRAKIDELREYLLRWGLYTPDQKHQKEPPFLWMGYELHPDKWT VQPITLPVKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCELLKGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10I, I15V, E35D, R41K, K45KR, L63P, Q92R, I93L, C95CF |
| >CA14926| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMNLPGKWKPRIIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLMTRLGFTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |