<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5998 CA14776 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 157
2 3TC+D4T+IDV 180

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V, T215Y K219Q     K101Q, K122E, T131TP, E169D, D177E, V179VI, G196E, T200A, E203ED, Q207E, H208HY, F214L, V245T, E248V, A272P, R284K, I293V K281KE
>CA14776| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFPIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIII
YQYVDDLYVGSDLEIEQHRAKIDELREYLLRWGLYTPDQKHQKEPPFLWMGYELHPDKWT
VQPITLPVKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCELLKGTKALTEVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L90M   L10I, I15V, E35D, R41K, K45KR, L63P, Q92R, I93L, C95CF  
>CA14926| codons 1-99
PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMNLPGKWKPRIIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLMTRLGFTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005