Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3932 | CA14759 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 60 |
| 2 | 3TC+ D4T+ RTV | 30 |
| 3 | 3TC+ DDI+ RTV+ SQV | 17 |
| 4 | 3TC+ AZT+ NVP | 43 |
| 5 | DDI+ D4T+ DLV+ NFV | 50 |
| 6 | NFV+ ABC+ ADV+ EFV | 45 |
| 7 | APV+ ABC+ EFV | 18 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K101E, Y181YC, G190A | A98G, V108VI, V179VF | V35I, E44ED, R83K, V106I, V118I, D123E, I135T, E138A, V189VI, Q197QH, T200A, E203K, Q207E, H208Y, R211K, K223E, T286A, A288S, E297K | P1S |
| >CA14759| codons 1-300 SISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLEKKKSITILDVGDAYFSIPL DKEFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIFI CQYMDDLYIASDLEIGHHRAKIKELREYLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I50IV, I54V, V82T, L90M | F53FL | L10I, I15V, K20R, E35D, M36I, N37E, L63P, A71AV |
| >CA14828| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIELPGRWKPKIIGGVGGLVKVRQYD QIPIEICGHKVIGTVLVGPTPTNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |