Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5982 | CA14754 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 82 |
| 2 | 3TC+DDI+NFV | 13 |
| 3 | 3TC+NFV+NVP | 84 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | Y181C | K122E, T139R, S162C, S163SG, I178L, R211AT, A272P, K277R, T286TA, E297K, I329L, M357T, R358RK, A376S, V381I, T386I, A400I, V435VI, D460N, L491S, E529D, Q547K, A554ST |
| >CA14754| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNERPGIRYQYNVLPQGWKGSPAIFQCGMTKILEPFRKQNPDLVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLLAWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKISTESIIIWGKIPKFKLPIQKETWEIWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLTDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKDKVYLAWVPAHK GIGGNEKVDKLVSTGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | K20I, M36I, I62V, L63P, I64IV, I72V, T74S |
| >CA14904| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD QVPVEICGHKAVGSVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |