Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5981 | CA14753 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | 3TC+AZT | 109 |
| 3 | 3TC+AZT+RTV | 74 |
| 4 | DDI+DLV+NFV | 17 |
| 5 | D4T+DLV+RTV+SQV | 65 |
| 6 | ABC+APV+DDI | 45 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K103N, Y181C, G190A | K20R, T39A, K43E, E44EA, K122P, Q174R, E203D, Q207E, H208Y, R211K, A288S, I293V, P294PA, E297K, A304G |
| >CA14753| codons 1-304 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYMDDLYVASDLEIGQHRTKIDELREYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVALTKEAE LELG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IV, I84V, L90M | L10I, K20R, E35D, M36I, N37S, R41K, I62V, L63P, A71V, P79S |
| >CA14903| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDISLPGKWKPKLIGGIGGFVKVRQYD QVPIEICGHKVIGTVLVGSTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |