Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4014 | CA14735 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | 3TC+AZT | 19 |
| 3 | 3TC+DDI | 4 |
| 4 | None | 4 |
| 5 | 3TC+D4T | 21 |
| 6 | 3TC+D4T+IDV | 34 |
| 7 | None | 20 |
| 8 | EFV+ADV | 10 |
| 9 | ABC+EFV+ADV | 12 |
| 10 | ADV+DDI+EFV | 7 |
| 11 | DDI+EFV | 21 |
| 12 | 3TC+AZT+NFV | 3 |
| 13 | 3TC+AZT+NFV | 40 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | E44D, E53D, A98S, K122A, E169D, D177E, G196E, T200A, Q207E |
| >CA14735| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPDNPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRAKIEELREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | R41RS, I64V |
| >CA14869| codons 11-99 VTIKIGGQLKEALLDTGADDTVLEEMNLPGSWKPKIIGGIGGFVKVRQYDQILVEICGHK AIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |