Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA4014 | CA14735 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 78 |
2 | 3TC+AZT | 19 |
3 | 3TC+DDI | 4 |
4 | None | 4 |
5 | 3TC+D4T | 21 |
6 | 3TC+D4T+IDV | 34 |
7 | None | 20 |
8 | EFV+ADV | 10 |
9 | ABC+EFV+ADV | 12 |
10 | ADV+DDI+EFV | 7 |
11 | DDI+EFV | 21 |
12 | 3TC+AZT+NFV | 3 |
13 | 3TC+AZT+NFV | 40 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, D67N, M184V, L210W, T215Y | E44D, E53D, A98S, K122A, E169D, D177E, G196E, T200A, Q207E |
>CA14735| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPDNPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DADFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRAKIEELREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQ |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
M46I, I54V, V82A | R41RS, I64V |
>CA14869| codons 11-99 VTIKIGGQLKEALLDTGADDTVLEEMNLPGSWKPKIIGGIGGFVKVRQYDQILVEICGHK AIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
Author | Title | Citation |
Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |