Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1484 | CA14619 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 152 |
| 2 | AZT+DDC | 82 |
| 3 | AZT+D4T | 26 |
| 4 | 3TC+AZT+D4T | 8 |
| 5 | 3TC+D4T+IDV | 108 |
| 6 | D4T+DDI+NFV+SQV | 89 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | F53L, G73GS | L10V, N37D, L63P, A71V, I93L |
| >CA14619| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGLVKVRQYD QIPIEICGHKVISTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, L210W, T215Y | K219R | V21I, E28K, K32E, V60I, R83K, K122E, S162Y, E169D, D177E, I178L, R211K, A272P | Q258Q*HY, K259K* |
| >CA14514| codons 1-287 PISPIETVPVKLKPGMDGPKIKQWPLTKEKIEALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRKQNPELVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIY*LVGKLNWASQIYPGIKVKQLCKLLRGTK |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |