Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1433 | CA14562 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 9 |
| 2 | AZT+ DDC | 11 |
| 3 | AZT | 42 |
| 4 | None | 2 |
| 5 | IDV | 5 |
| 6 | D4T+IDV | 37 |
| 7 | None | 11 |
| 8 | DDI+RTV+SQV | 19 |
| 9 | RTV+SQV | 8 |
| 10 | None | 4 |
| 11 | 3TC+ADV+DDI+EFV+NFV+SQV | 30 |
| 12 | ADV+EFV+NFV+SQV | 3 |
| 13 | ADV+D4T+EFV+NFV+SQV | 14 |
| 14 | ADV+D4T+EFV | 2 |
| 15 | 3TC+ABC+ADV+D4T+EFV | 9 |
| 16 | 3TC+ABC+EFV | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, M230L | V108I | A98S, V118VI, D121HY, K122E, Q207E, R211K, K277KR, I293V |
| >CA14562| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTILDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWLGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10V, E35D, M36I, R57K, L63P, A71V, I93L |
| >CA14668| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKLIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |