Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA701 | RENA701 | Brazil | 2004 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+IDV | 43 |
| 2 | Unknown | 4 |
| 3 | AZT+DDI+LPV | 9 |
| 4 | 3TC+AZT+LPV | 4 |
| 5 | 3TC+AZT+EFV | 2 |
| 6 | Unknown | 24 |
| 7 | 3TC+AZT+NVP | 31 |
| 8 | Unknown | 4 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I15V, K20R, M36I, R41K, R57K, Q61D, L63P, K70R, I72V, I93L |
| >RENA701| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVKQYD DIPIEICGHRAVGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K32I, V35T, D123E, I142V, E169D, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, Q278H, T286A, E291D, V292I, I293V, E297A, V317A, S322T, Q334H |
| >RENA701| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIIALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPELVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGAYYDPTKDLIAEIQKQGHG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |