<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
RENA701 RENA701 Brazil 2004 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+IDV 43
2 Unknown 4
3 AZT+DDI+LPV 9
4 3TC+AZT+LPV 4
5 3TC+AZT+EFV 2
6 Unknown 24
7 3TC+AZT+NVP 31
8 Unknown 4

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I15V, K20R, M36I, R41K, R57K, Q61D, L63P, K70R, I72V, I93L  
>RENA701| codons 1-99
PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVKQYD
DIPIEICGHRAVGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K32I, V35T, D123E, I142V, E169D, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, Q278H, T286A, E291D, V292I, I293V, E297A, V317A, S322T, Q334H  
>RENA701| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIIALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPELVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGAYYDPTKDLIAEIQKQGHG

References
Author Title Citation
Dumans, AT Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. Infect Genet Evol, 2009