Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA332 | RENA332 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 56 |
| 2 | 3TC+D4T+IDV | 96 |
| 3 | AZT+DDI+RTV+SQV | 65 |
| 4 | 3TC+AZT+IDV+NFV+RTV | 74 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10V, K20R, E35D, M36I, R41K, D60E, Q61D, I62V, L63P, H69Y, I72T, L89M |
| >RENA332| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYE DVPIEICGYKATGTVLVGPTPVNVIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219EQ | Y181C | V179D | K20R, V90I, K102Q, K103R, D123E, I135V, S162C, E169D, K173A, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, A288T, E291D, V292I, I293V, E297A, V317A |
| >RENA332| codons 1-335 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKQRKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDIDI CQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKTLTDIVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |