<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
RENA166 RENA166 Brazil 2002 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 52
2 3TC+AZT+RTV 13
3 3TC+AZT+NFV 22
4 D4T+DDI+EFV+RTV+SQV 113
5 3TC+APV+AZT+EFV+RTV 8
6 3TC+AZT+IDV+NVP+RTV 17

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T215F   K103N, V106M   K20R, I135V, S162C, K173A, Q174K, T200A, Q207E, R211K, V245Q, T286V, E291D, V292I, I293V, E297P, V317A, D324E, Q332H  
>RENA166| codons 1-335
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSMTVLDVGDAYFSVPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGVKALTDIVPLTPEAE
LELAENREILKEPVHGAYYDPSKELIAEIQKHGQG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I15V, G16E, E35D, M36I, P39T, R41K, R57K, Q61N, L63V, I72T, L89M  
>RENA166| codons 1-99
PQITLWQRPVVTIKVEGQLKEALLDTGADDTVLEDINLTGKWKPKMIGGIGGFIKVKQYD
NIVIEICGHKATGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Dumans, AT Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. Infect Genet Evol, 2009