Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA166 | RENA166 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 52 |
| 2 | 3TC+AZT+RTV | 13 |
| 3 | 3TC+AZT+NFV | 22 |
| 4 | D4T+DDI+EFV+RTV+SQV | 113 |
| 5 | 3TC+APV+AZT+EFV+RTV | 8 |
| 6 | 3TC+AZT+IDV+NVP+RTV | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I15V, G16E, E35D, M36I, P39T, R41K, R57K, Q61N, L63V, I72T, L89M |
| >RENA166| codons 1-99 PQITLWQRPVVTIKVEGQLKEALLDTGADDTVLEDINLTGKWKPKMIGGIGGFIKVKQYD NIVIEICGHKATGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215F | K103N, V106M | K20R, I135V, S162C, K173A, Q174K, T200A, Q207E, R211K, V245Q, T286V, E291D, V292I, I293V, E297P, V317A, D324E, Q332H |
| >RENA166| codons 1-335 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSMTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGVKALTDIVPLTPEAE LELAENREILKEPVHGAYYDPSKELIAEIQKHGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |