Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA244 | RENA244 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+RTV | 69 |
| 2 | 3TC+D4T+RTV+SQV | 44 |
| 3 | 3TC+D4T+IDV | 52 |
| 4 | 3TC+AZT+NFV+NVP | 30 |
| 5 | 3TC+AZT+EFV | 39 |
| 6 | Unknown | 65 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, T215F | K219Q | K103N, G190A | E6D, V35T, V60I, V90I, K102N, S117A, D121H, K122E, I135T, S162Y, E169D, P170L, F171Y, Q174K, D177E, G196E, T200A, E203D, Q207E, L228H, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, E297A, V317A |
| >RENA244| codons 1-335 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEIQLGIPHPAGLKNNKSVTVLDVGDAYFAVPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDLYRKKNPEIVI YQYMDDLYVASDLEIEQHRAKIDELREHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, L76V, V82A, L90M | L10V, I15V, K20R, E34A, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63P, A71V, I93M |
| >RENA244| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLADINLPGKWKPKIIGGVGGFIKVKQYE DVPIEICGHKVIGTVVVGPTPANIIGRNLMTQMGCTLNF |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |